4-hydroxynonenal-lysine

4-hydroxynonenal-lysine is an epitope generated by the oxidative modification of low-density lipoprotein.[1] It is formed by the direct addition of carbonyl groups from 4-hydroxynonenal (HNE) onto lysine.[2]

References
  1. "ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum". Atvb.ahajournals.org. Retrieved September 9, 2015.
  2. Madian, AG; Regnier, FE (2010). "Proteomic Identification of Carbonylated Proteins and Their Oxidation Sites". J. Proteome Res. 9 (8): 3766–80. doi:10.1021/pr1002609. PMC 3214645. PMID 20521848.


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