Cumomer

A cumomer is a cumulative isotopomer and is a concept that relates to metabolic flux analysis. The concept was developed in 1999.

Description

A cumomer is a cumulative isotopomer. The concept relates to metabolic flux analysis.

History

The concept was developed in 1999.[1][2]

Metabolic flux analysis

Given a molecule as a set of atoms—any of which could be (isotopically) labeled—the cumomers are a set of isotopomers with particular positions of 13C-labels grouped into different levels depending on the amount of labeled atoms. At level 0, any position can be either 12C or 13C. At level 1, one position is 13C whether the others may or may not be labeled and so on.

References
  1. Wiechert W, Möllney M, Isermann N, Wurzel M, de Graaf AA (1999). "Bidirectional reaction steps in metabolic networks: III. Explicit solution and analysis of isotopomer labeling systems". Biotechnology and Bioengineering. 66 (2): 69–85. doi:10.1002/(SICI)1097-0290(1999)66:2<69::AID-BIT1>3.0.CO;2-6. PMID 10567066.
  2. Yang TH, Frick O, Heinzle E (March 2008). "Hybrid optimization for 13C metabolic flux analysis using systems parametrized by compactification". BMC Systems Biology. 2 (1): 29. doi:10.1186/1752-0509-2-29. PMC 2333969. PMID 18366780.

Further reading
  • Yang TH (2013). "13C-based metabolic flux analysis: fundamentals and practice". Systems Metabolic Engineering. Methods in Molecular Biology. Vol. 985. Clifton, N.J. pp. 297–334. doi:10.1007/978-1-62703-299-5_15. ISBN 978-1-62703-298-8. PMID 23417810.
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