Evil West

Jesse Rentier, one of the last agents of a clandestine vampire-hunting organization, must protect the American frontier from supernatural monstrosities.[3]

Jesse Rentier is an agent of the Rentier Institute, a secret organization dedicated to battling supernatural creatures such as the Sanguisuge, vampires that prey on humanity. Working together with retired agent Edgar Gravenor, they follow the trail of Peter D'Abano, a high ranking vampire that advocates for declaring war on humanity before their technology develops to the point where it will become a threat to the Sanguisuge. The Sanguisuge leadership, wanting to stay in the shadows, reject D'Abano's plan and sentence him and his entire line to death. Jesse and Edgar then ambush D'Abano and capture his head, taking it back to the Manor, the Rentier Institute's headquarters.

Upon arriving, Jesse is given a special Gauntlet by his father William who reveals it is capable of breaking the magical Glamours the Sanguisuge use to hide themselves. During a presentation of the Gauntlet in front of Assistant Secretary of War James Harrow, D'Abano's daughter Felicity attacks the Manor, killing most of the staff and agents stationed there and recovering D'Abano's head. With William critically wounded, Jesse, Edgar, and Harrow flee to the nearby city of Calico where they make contact with the local Rentier Institute cell, led by Emilia Blackwell. Suspecting that William may have been infected with vampirism by Felicity, Edgar heads off by himself to find a possible cure for the infection while Jesse works to repair the Gauntlet.

While recovering the parts needed to repair the Gauntlet, Jesse finds that Felicity has been siphoning blood from ancient prehistoric beasts to create her own army of creatures called foulbloods. Meanwhile, Felicity and D'Abano have also managed to purchase an oil field company called Andalusia and a train manufacturer called Persephone to distribute infected leeches and bats around the country. He destroys Felicity's blood source and returns to Calico to find that his father has indeed been infected by vampire blood and is in the process of turning into Felicity's Familiar. With time short, Jesse heads out to find Edgar and the cure and injects it into William. However, William is still briefly telepathically linked with Felicity and warns Jesse she is in Dickinson, an important rail hub. Jesse heads to Dickinson, but is unable to prevent Felicity from escaping. After suffering significant injury, Jesse is rescued by a local pastor who offers to send a telegram back to the Institute in exchange for destroying the local monster nests. Upon returning to Calico, Jesse heads to an abandoned Rentier Institute lab with engineer Vergil Olney to further upgrade his Gauntlet.

After increasing the Gauntlet's power, Jesse is confronted by Harrow, who has discovered they have kept William alive in violation of protocol - he orders him to kill William. When Jesse and the rest of the Calico cell refuse, Harrow leaves, promising to withdraw the US government's support. Jesse then reunites with Edgar (who is surprised to see Jesse alive after the incident in Dickinson), and learn from their vampire informant Chester that Felicity is planning to attack Washington D.C. Chester also warns them that the cure they used on William is only temporary, and will not stop him from eventually turning. Jesse and Edgar rush back to Calico, but arrive to find out that William had turned in their absence, killed several members of the Calico cell, and then fled. Realizing his father is too far gone, Jesse promises to hunt William down.

Jesse follows William's trail to Felicity's base in Persephone, where he reluctantly kills him. He then proceeds to Felicity's headquarters in Carmine City, where she is using the local bank to finance her activities. While Felicity is already gone, Jesse recaptures D'Abano, who under interrogation reveals Felicity has already left to ambush President Grover Cleveland so she can turn him. Jesse and his friends follow Felicity. While his friends secure President Cleveland, Jesse confronts Felicity and manages to kill her.

Emilia informs President Cleveland of how Harrow has been abusing his position for profit, leading to his arrest and dismissal. President Cleveland then promises to reinstate the Rentier Institute and give it his full backing. Knowing that the war against the Sanguisuge is far from over, Jesse and Emilia begin to come up with ideas to rebuild and reform the Rentier Institute.