HOPO 14-1

HOPO 14-1 is an investigational drug product for removing radioactive contaminants from the body. It is designed to act as a defence against radioactive threats such as dirty bomb attacks.[1][2] The active ingredient is the hydroxypyridinone ligand 3,4,3-LI(1,2-HOPO), which is a powerful chelating agent.[1][3]

3,4,3-LI(1,2-HOPO)
Legal status
Legal status
  • Investigational
Identifiers
  • N,N′-1,4-Butanediylbis[N-[3-[[(1,6-dihydro-1-hydroxy-6-oxo-2-pyridinyl)carbonyl]amino]propyl]-1,6-dihydro-1-hydroxy-6-oxo-2-pyridinecarboxamide]
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC34H38N8O12
Molar mass750.722 g·mol−1
3D model (JSmol)
  • O=C1C=CC=C(C(=O)NCCCN(C(=O)C2=CC=CC(=O)N2O)CCCCN(C(=O)C3=CC=CC(=O)N3O)CCCNC(=O)C4=CC=CC(=O)N4O)N1O
  • InChI=1S/C34H38N8O12/c43-27-13-3-9-23(39(27)51)31(47)35-17-7-21-37(33(49)25-11-5-15-29(45)41(25)53)19-1-2-20-38(34(50)26-12-6-16-30(46)42(26)54)22-8-18-36-32(48)24-10-4-14-28(44)40(24)52/h3-6,9-16,51-54H,1-2,7-8,17-22H2,(H,35,47)(H,36,48)
  • Key:KUWKQASGHNTJAT-UHFFFAOYSA-N

References
  1. "First-in-human trial of oral drug to remove radioactive contamination begins". National Institutes of Health (NIH). 2023-05-15. Retrieved 2023-05-16.
  2. Roberts M (2023-05-16). "Dirty-bomb antidote: Drug trial begins in US". BBC News. Retrieved 2023-05-16.
  3. Wang Q, Liu Z, Song YF, Chai Z, Wang D (March 2023). "Chelation Behaviors of 3,4,3-LI(1,2-HOPO) with Lanthanides and Actinides Implicated by Molecular Dynamics Simulations". Inorganic Chemistry. 62 (10): 4304–4313. doi:10.1021/acs.inorgchem.2c04460. PMID 36847745. S2CID 257218983.

See also


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