Jue Chen (scientist)

Jue Chen (Chinese: 陈珏) is a Chinese-born American structural biologist and biochemist. She is the William E. Ford professor of biochemistry and head of the Laboratory of Membrane Biology and Biophysics at the Rockefeller University and a Howard Hughes Medical Institute investigator. Her research focuses on elucidating the structure and function of ATP-binding cassette (ABC) transporters.

The native form of this personal name is Chen Jue. This article uses Western name order when mentioning individuals.
Jue Chen
Born
China
CitizenshipUnited States
Alma mater
Known forStructural studies of ABC transporters
SpouseRoderick MacKinnon ( 2017-)
Scientific career
Institutions

Early life and education

Chen was born in Changsha, China and graduated from Changsha No. 1 High School in 1988. She studied at Tongji University in Shanghai before moving to the United States.[1][2]

She earned a bachelor's degree in chemistry from Ohio University in 1993, and went on to pursue PhD in biochemistry from Harvard University in 1998 under the mentorship of Don C. Wiley,[3] where she discovered unique structural features of the influenza virus responsible for infection [4][5][6]

Career and research

Chen remained in Don C. Wiley's lab as a postdoctoral researcher before moving on to a postdoctoral fellowship at Baylor College of Medicine from 1999 to 2001 in the lab of Florante A. Quiocho,[3] where she started studying the ATP binding cassette transporters[7]

In 2002, Chen became an assistant professor at Purdue University where she won a number of teaching awards and published her research in high impact journals.[8] In 2007, Chen was promoted to associate professor and subsequently, professor in 2011. In 2003 she was named a Pew Scholar and a Howard Hughes Medical Institute Investigator in 2008 [9] In 2014, she moved to The Rockefeller University,[10] where she is now the William E. Ford Professor and Head of Laboratory of Membrane Biology and Biophysics.[11]

Her work on ABC transporters includes investigating their role in resistance to chemotherapy drugs; antigen presentation in adaptive immunity and viral infection; cystic fibrosis; and bacterial nutrition.[3]

In 2019, she was elected to the National Academy of Sciences.[12]

Awards and honors

References
  1. Yu, Rong (2019-05-10). "长沙市一中校友陈珏当选美国国家科学院院士". Hunan Daily (in Chinese). Retrieved 2019-05-17.
  2. "Alumni News | Chen Elected to National Academy of Sciences". Ohio University | College of Arts & Sciences. 2019-06-06. Retrieved 2020-05-02.
  3. "The Rockefeller University » Lab Members". lab.rockefeller.edu. Retrieved 25 April 2019.
  4. Chen, Jue; Lee, Kon Ho; Steinhauer, David A; Stevens, David J; Skehel, John J; Wiley, Don C (October 1998). "Structure of the Hemagglutinin Precursor Cleavage Site, a Determinant of Influenza Pathogenicity and the Origin of the Labile Conformation". Cell. 95 (3): 409–417. doi:10.1016/s0092-8674(00)81771-7. ISSN 0092-8674. PMID 9814710. S2CID 11232474.
  5. Chen, J.; Skehel, J. J.; Wiley, D. C. (1999-08-03). "N- and C-terminal residues combine in the fusion-pH influenza hemagglutinin HA2 subunit to form an N cap that terminates the triple-stranded coiled coil". Proceedings of the National Academy of Sciences. 96 (16): 8967–8972. doi:10.1073/pnas.96.16.8967. ISSN 0027-8424. PMC 17716. PMID 10430879.
  6. Chen, Jue; Skehel, John J.; Wiley, Don C. (September 1998). "A Polar Octapeptide Fused to the N-Terminal Fusion Peptide Solubilizes the Influenza Virus HA2Subunit Ectodomain†". Biochemistry. 37 (39): 13643–13649. doi:10.1021/bi981098l. ISSN 0006-2960. PMID 9753451.
  7. Chen, Jue; Lu, Gang; Lin, Jeffrey; Davidson, Amy L; Quiocho, Florante A (September 2003). "A Tweezers-like Motion of the ATP-Binding Cassette Dimer in an ABC Transport Cycle". Molecular Cell. 12 (3): 651–661. doi:10.1016/j.molcel.2003.08.004. PMID 14527411.
  8. "Jue Chen, Ph.D." bit.ly. Retrieved 2020-07-12.{{cite web}}: CS1 maint: url-status (link)
  9. "Jue Chen". www.nasonline.org. Retrieved 2020-07-12.
  10. "Jue Chen". Our Scientists. Retrieved 25 April 2019.
  11. "Jue Chen". Our Scientists. Retrieved 2020-07-12.
  12. "2019 NAS Election". www.nasonline.org. Retrieved 2020-05-03.
  13. "2019 NAS Election". National Academy of Sciences. April 30, 2019.
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