Kentucky Route 375

Both of the route's termini are intersections with KY 163 southeast and north of Tompkinsville. It is one of the main thouroughfares in the city of Tompkinsville, with junctions with KY 1446 and then KY 63 and KY 100 in downtown Tompkinsville. At the intersection with KY 63 and KY 100, KY 375 turns on a northerly course to its second junction with KY 163 on the northern end of town.

In the 90 years since Kentucky's state highway system was established, KY 163 was the original north–south thoroughfare through the city of Tompkinsville. In 2020, KY 163 was rerouted to the new Tompkinsville Bypass, which was opened to traffic after almost three years since construction began in November 2017.[2] Once the bypass route was completed and opened to traffic in 2020, KY 163 was rerouted onto the bypass; the old alignment of KY 163 in Tompkinsville was redesignated as KY 375.[1]