Mainframe (disambiguation)
A mainframe computer is a type of large data processing system.

Look up mainframe in Wiktionary, the free dictionary.
Mainframe may also refer to:
- Mainframe Entertainment, a Canadian computer animation company that has alternated (3 times) under the Rainmaker banner due to majority interests acquisitions
- Either of two fictional Marvel Comics characters:
- Mainframe (comics), from the series A-Next
- Mainframe, a character from the Guardians of the Galaxy series
- Mainframe (G.I. Joe), a character in the G.I. Joe universe
- A character from the game Gunman Chronicles
- Mainframe, the city in which the animated series ReBoot takes place
- Tina "Mainframe" Cassidy, a character from COPS (animated TV series)
- A character in Gene Wolfe's novel/series The Book of the Long Sun
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