Mannosyl-oligosaccharide 1,2-alpha-mannosidase

Mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113, mannosidase 1A, mannosidase 1B, 1,2-alpha-mannosidase, exo-alpha-1,2-mannanase, mannose-9 processing alpha-mannosidase, glycoprotein processing mannosidase I, mannosidase I, Man9-mannosidase, ManI, 1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase) is an enzyme with systematic name 2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase.[1][2] This enzyme catalyses the following chemical reaction

Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2
Mannosyl-oligosaccharide 1,2-alpha-mannosidase
Identifiers
EC no.3.2.1.113
CAS no.9068-25-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins

This enzyme is involved in the synthesis of glycoproteins.

Kifunensine is a potent inhibitor of mannosidase I.

References
  1. Tabas I, Kornfeld S (November 1979). "Purification and characterization of a rat liver Golgi α-mannosidase capable of processing asparagine-linked oligosaccharides". The Journal of Biological Chemistry. 254 (22): 11655–63. doi:10.1016/s0021-9258(19)86534-1. PMID 500665.
  2. Tulsiani DR, Hubbard SC, Robbins PW, Touster O (April 1982). "α-D-Mannosidases of rat liver Golgi membranes: Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases IA and IB are the enzymes converting Man9 precursors to Man5 intermediates". The Journal of Biological Chemistry. 257 (7): 3660–8. doi:10.1016/s0021-9258(18)34831-2. PMID 7061502.
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