Mann Kee Awaaz Pratigya

• Pooja Gor as Pratigya Saxena / Pratigya Krishna Singh Thakur: Naina and Shyam's elder daughter; Adarsh and Aarushi's sister; Krishna's wife; Samar's adoptive mother; Kriti's mother (2009−2012) [4]
• Arhaan Behll as Krishna Singh Thakur: Sajjan and Sumitra's younger son; Shakti and Komal's brother; Abhimanyu's half-brother; Pratigya's husband; Samar's adoptive father; Kriti's father (2009−2012) [5][6]

• Parvati Sehgal as Komal Singh Thakur / Komal Adarsh Saxena: Sajjan and Sumitra's daughter; Shakti and Krishna's younger sister; Abhimanyu's half-sister; Adarsh's widow; Kartik's wife; Chinky's mother.[7][8]
• Shahab Khan as Shyam Saxena: Naina's husband; Adarsh, Pratigya and Aarushi's father; Chinky and Kriti's grandfather.
• Monica Singh as Naina Shyam Saxena: Shyam's wife; Adarsh, Pratigya and Aarushi's mother; Chinky and Kriti's grandmother. (Dead) (Episode 1 (9 December 2009) – Episode 426 (26 July 2011)
• Avantika Hundal as Aarushi Saxena: Naina and Shyam's younger daughter; Adarsh and Pratigya's younger sister; Shakti and Tanmay's ex-wife.
• Kunal Karan Kapoor as Angad Yadav: Thug; Pratigya and Komal's foe (2010) (Dead)
• Ankit Gera / Aniruddh Singh as Adarsh Saxena: Naina and Shyam's son; Pratigya and Aarushi's elder brother; Komal's husband; Chinky's father.[9] (Dead)
• Unknown as Chinky Saxena: Adarsh and Komal's daughter.
• Arya Kumar / Malhar Pandya as Kartik Saxena: Komal's second husband
• Anupam Shyam as Sajjan Singh Thakur: Sumitra's husband; Shakti, Krishna, Komal and Abhimanyu's father; Chinky, Samar and Kriti's grandfather.[10]
• Asmita Sharma as Sumitra Sajjan Singh Thakur: Sankata's sister; Sajjan's wife; Shakti, Krishna and Komal's mother; Chinky, Samar and Kriti's grandmother.
• Jaswant Menaria as Shakti Singh Thakur: Sajjan and Sumitra's elder son; Krishna and Komal's elder brother; Abhimanyu's half-brother; Kesar and Menaka's husband; Samar's father; Aarushi's ex–husband
• Kalpna Bohra / Aalika Sheikh as Kesar Shakti Singh Thakur: Shakti's first wife; Samar's mother [11]
• Eklavya Ahir as Samar Singh Thakur: Kesar and Shakti's son; Krishna and Pratigya's adoptive son
• Soni Singh as Menaka Shakti Singh Thakur: Shakti's second wife
• Asha Sharma as Mrs. Saxena: Shyam's mother; Adarsh, Pratigya and Aarushi's grandmother
• Mohit Malik as Advocate Abhimanyu Singh Yadav: Sajjan and Shakuntala's son; Shakti, Krishna and Komal's half-brother
• Abhishek Rawat as Tanmay Srivastav: Aarushi's ex-husband
• Amita Udgata as Mrs. Singh Thakur: Sajjan's mother; Shakti, Krishna, Komal and Abhimanyu's grandmother
• Akhilendra Mishra as Sankata Singh: Sumitra's brother
• Sana Amin Sheikh as Ganga: Sajjan's mistress (2011)
• Deeya Chopra as Anu Aman Mathur: Aman's wife
• Piyush Sahdev as Advocate Aman Mathur: Sarveshwardayal's middle son; Gaurav's younger brother; Jay's elder brother; Aarushi's ex-fiancé (2010–2011)
• Sehrish Ali as Roli: Pratigya's best friend; Adarsh's lover (2010)
• Manmohan Tiwari as Radhe
• Prachi Pathak as Maayi
• Kunal Jaisingh as Sarang "Gunga" (2011)
• Sachin Sharma as Gaurav Mathur: Sarveshwardayal's elder son; Aman and Jay's elder brother; Nandini's husband (2010)
• Chetan Pandit as I.G. Sarveshwardayal Mathur: Gaurav, Aman and Jay's father; Nandini's father–in–law (2010)
• Kunal Madhiwala as Lucky
• Dinesh Soi as Jugnu
• Vinay Rajput as Tunna
• Pratima Kazmi as Guru Maa
• Sonal Jha as Shakuntala:[12] Sajjan's mistress; Abhimanyu's mother (2012)
• Nirbhay Wadhwa as Goon
• Mayank Arora as Jay Mathur: Sarveshwardayal's younger son; Gaurav and Aman's younger brother (2010)
• Raj Premi as Makhnu Singh
• Jaydeep Suri as Chandu
• Abner Reginald as Judge (in Angad Yadav murder case) (2010)
• Ruchi Savarn as Sunehri (2011)
• Chaitanya Choudhury as Abhishek: Neelima's husband; Pratigya's college friend (2011)
• Akanksha Juneja as Neelima: Abhishek's wife; Pratigya's college friend (2011)
• Neha Kaul as Meera: Krishna's one–sided lover (2011)
• Deepika Singh as Sandhya
• Sanaya Irani as Khushi
• Manasi Parekh as Gulaal

As a part of promotion of the series before its launch, in December 2009, a campaign was done as Meri Pratigya at Nariman Point in Mumbai where along with lead Pooja Gor, 500 women as a chain to create an awareness on eve-teasing and ill treatment of women.[15]

Parvati Sehgal who played Komal's role in the show was originally approached for Aarushi's role but got rejected because of a look test but later got selected for Komal's role when she was approached for the second time.[16]

Falaq Naaz was originally signed to play an uneducated village girl Shakun in the show who was Abhimanyu's wife but things couldn't work out as she chose another show of Star Plus Khamoshiyan later her role got scrapped from the show.[17] Rohit Khurana was finalized for Krishna's role but rejected it as he was busy with Uttaran at that time.

In mid 2011, Monica Singh playing Naina quit the series and was hoped for coming back after a break. However, as she refused returning, the makers decided to end her character and she agreed to shoot for two days but did not turn up. Thus, her character was mentioned dead in a car accident.[18]

The series was off aired in October 2012. In early 2013, the series was confirmed returning with a new season based on story of lead character Pratigya and Krishna's daughters.[19][20] Neha Marda was roped as one of the leads and the pilot episode was shot and approved by the channel but the series was dropped when the discussions between the production house and channel stalled.[21] However, on 19 February 2021, the series was confirmed returning with a new season on Star Bharat.[22][23] Mann Kee Awaaz Pratigya 2 premiered on 15 March 2021, is produced by former season producer Pearl Grey along with Rajan Shahi under Director's Kut Productions.[24]

Based on the backdrop of Uttar Pradesh, Allahabad, the series was mainly filmed at sets in Film city in Mumbai while some sequences were also shot at Allahabad.[25]

The Indian Express stated, "It's a perfect Hindi heartland show - over-the-top drama and aggressive, regressive as well as progressive in characters and content."[26]

In November 2010, Deccan Herald criticised, "The serial that broke many a record on Star Plus because of its unique anti-eve teasing storyline, seems to have changed track completely. Today, it’s boiled down to a tale where a woman is humiliated at home, her self respect trampled on by her in-laws and husband instead of portraying her to be a strong woman who stands her ground."[27]

The Hindu criticised, "From the current crop of serials, a very good example of enthusiastic consumption of a bizarre plot line is the serial “Mann ki Awaaz Pratigya”. The production house, Star TV, bills it a “fight against disrespect of women”. And what does the lead character do? She marries a goon who eve-teases her. Then she tells him that he can win her body but not her love. You fight disrespect by marrying the eve-teaser, taking the battle into his home."[28]

Pratigya opened with a rating of 3.7 TVR.[29] As in April 2010, it was one of the top ten Hindi GEC which garnered 4.5 TVR.[30] As in July 2010, it was at second position with ratings ranging 4 to 5.3 TVR.[31] In weeks 24 and 25 of 2010, it garnered 4.8 and 5.5 TVRs.[32][33] In week 4 of 2011, it garnered 5.7 TVR.[34] As in week 29 of 2011, it dropped to 3.9 TVR while its peak ratings garnered were around 6 TVR in its run time.[26] In the week ending 27 September 2011, it garnered 4.27 TVR occupying fourth position.[35] When the ratings dropped ranging between 2 and 2.5 TVR, it was off aired on October 2012.[36]