NOVA1

NOVA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DT4, 2ANN, 2ANR
Identifiers
Aliases	NOVA1, Nova-1, NOVA alternative splicing regulator 1
External IDs	OMIM: 602157 MGI: 104297 HomoloGene: 21296 GeneCards: NOVA1
Gene location (Human)
Chr.	Chromosome 14 (human)[1]
End	26,597,754 bp[1]
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)[2]
End	46,818,929 bp[2]
RNA expression pattern
	Top expressed in
	cerebellum; ; cerebellar hemisphere; ; hypothalamus; ; Brodmann area 46; ; prefrontal cortex; ; pons; ; synovial joint; ; ganglionic eminence; ; dorsolateral prefrontal cortex; ; superior vestibular nucleus;
	Top expressed in
	dorsomedial hypothalamic nucleus; ; lateral hypothalamus; ; paraventricular nucleus of hypothalamus; ; medial vestibular nucleus; ; cerebellar cortex; ; superior colliculus; ; inferior colliculus; ; ventromedial nucleus; ; dorsal tegmental nucleus; ; ventral tegmental area;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleic acid binding; mRNA binding; RNA binding; protein binding;
Cellular component	nucleolus; intracellular membrane-bounded organelle; nucleus;
Biological process	mRNA splicing, via spliceosome; RNA processing; locomotory behavior; RNA splicing; regulation of RNA metabolic process; chemical synaptic transmission; negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	4857
	664883
	ENSG00000139910
	ENSMUSG00000021047
	P51513
	Q9JKN6
	NM_002515; NM_006489; NM_006491
NM_021361; NM_001364634; NM_001364635; NM_001364636; NM_001364637;
	NM_001364638; NM_001364639
NP_002506; NP_006480; NP_006482; NP_001353319; NP_001353320;
	NP_001353321; NP_001353322; NP_001353323; NP_001353324; NP_001353325; NP_001353326; NP_001353327
NP_067336; NP_001351563; NP_001351564; NP_001351565; NP_001351566;
	NP_001351567; NP_001351568
	Wikidata
View/Edit Human	View/Edit Mouse

RNA-binding protein Nova-1 is a protein that in humans is encoded by the NOVA1 gene.[5][6]

This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described.[6] Both Neanderthals and Denisovans had one version and nearly all modern humans had another suggesting positive selection. Insertion of Neanderthal gene variant of the neuro-oncological ventral antigen 1 (NOVA1) gene into human cortical organoids promoted slower development and higher surface complexity in the brain models.[7]

References

GRCh38: Ensembl release 89: ENSG00000139910 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021047 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Buckanovich RJ, Yang YY, Darnell RB (Feb 1996). "The onconeural antigen Nova-1 is a neuron-specific RNA-binding protein, the activity of which is inhibited by paraneoplastic antibodies". J Neurosci. 16 (3): 1114–22. doi:10.1523/JNEUROSCI.16-03-01114.1996. PMC 6578795. PMID 8558240.
"Entrez Gene: NOVA1 neuro-oncological ventral antigen 1".
"Neanderthal Gene Variant Alters Neurodevelopment in Human Brain Organoids". 11 February 2021.

Buckanovich RJ, Posner JB, Darnell RB (1993). "Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system". Neuron. 11 (4): 657–72. doi:10.1016/0896-6273(93)90077-5. PMID 8398153. S2CID 22554933.
Buckanovich RJ, Darnell RB (1997). "The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo". Mol. Cell. Biol. 17 (6): 3194–201. doi:10.1128/MCB.17.6.3194. PMC 232172. PMID 9154818.
Lewis HA, Chen H, Edo C, et al. (1999). "Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains". Structure. 7 (2): 191–203. doi:10.1016/S0969-2126(99)80025-2. PMID 10368286.
Jensen KB, Dredge BK, Stefani G, et al. (2000). "Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability". Neuron. 25 (2): 359–71. doi:10.1016/S0896-6273(00)80900-9. PMID 10719891.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Dredge BK, Darnell RB (2003). "Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer". Mol. Cell. Biol. 23 (13): 4687–700. doi:10.1128/MCB.23.13.4687-4700.2003. PMC 164843. PMID 12808107.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ule J, Ule A, Spencer J, et al. (2005). "Nova regulates brain-specific splicing to shape the synapse". Nat. Genet. 37 (8): 844–52. doi:10.1038/ng1610. PMID 16041372. S2CID 8446567.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000139910 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021047 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8558240-5] Buckanovich RJ, Yang YY, Darnell RB (Feb 1996). "The onconeural antigen Nova-1 is a neuron-specific RNA-binding protein, the activity of which is inhibited by paraneoplastic antibodies". J Neurosci. 16 (3): 1114–22. doi:10.1523/JNEUROSCI.16-03-01114.1996. PMC 6578795. PMID 8558240.

[entrez-6] "Entrez Gene: NOVA1 neuro-oncological ventral antigen 1".

[7] "Neanderthal Gene Variant Alters Neurodevelopment in Human Brain Organoids". 11 February 2021.

NOVA1

References

Further reading