Cytosol nonspecific dipeptidase

Cytosolic non-specific dipeptidase (EC 3.4.13.18) also known as carnosine dipeptidase 2 is an enzyme that in humans is encoded by the CNDP2 gene.[5][6][7] This enzyme catalyses the following chemical reaction

Hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids
CNDP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCNDP2, CN2, CPGL, HEL-S-13, HsT2298, PEPA, CNDP dipeptidase 2 (metallopeptidase M20 family), carnosine dipeptidase 2
External IDsOMIM: 169800 MGI: 1913304 HomoloGene: 10085 GeneCards: CNDP2
Orthologs
SpeciesHumanMouse
Entrez

55748

66054

Ensembl

ENSG00000133313

ENSMUSG00000024644

UniProt

Q96KP4

Q9D1A2

RefSeq (mRNA)

NM_001289531
NM_023149

RefSeq (protein)

NP_001276460
NP_075638

Location (UCSC)Chr 18: 74.5 – 74.52 MbChr 18: 84.69 – 84.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Cytosol nonspecific dipeptidase
Identifiers
EC no.3.4.13.18
CAS no.9025-31-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

This zinc enzyme has broad specificity.

Nomenclature

Cytosolic non-specific dipeptidase is also known as

  • N2-beta-alanylarginine dipeptidase
  • glycyl-glycine dipeptidase
  • glycyl-leucine dipeptidase
  • iminodipeptidase
  • peptidase A
  • Pro-X dipeptidase
  • prolinase
  • prolyl dipeptidase
  • prolylglycine dipeptidase
  • L-prolylglycine dipeptidase
  • diglycinase
  • Gly-Leu hydrolase
  • glycyl-L-leucine dipeptidase
  • glycyl-L-leucine hydrolase
  • glycyl-L-leucine peptidase
  • L-amino-acyl-L-amino-acid hydrolase
  • glycylleucine peptidase
  • glycylleucine hydrolase
  • glycylleucine dipeptide hydrolase
  • non-specific dipeptidase
  • human cytosolic non-specific dipeptidase

Dipeptidase is a type of peptidase, which is a type of hydrolase. Other term with the suffix -ase denotes enzymes acting on the substrate with the suffix. Beta-alanyl is an acyl group derived from beta-alanine. N2-beta-alanylarginine is a dipeptide of beta-alanine and arginine. Glycyl is an acyl group derived from glycine. Glycyl-glycine or diglycine is a dipeptide of two glycine (Gly) molecules. Glycyl-leucine, glycylleucine, glycyl-L-leucine, or Gly-Leu is a dipeptide of glycine and leucine (Leu). Prolyl is an acyl group derived from proline (Pro). Pro-X is a dipeptide of proline and another amino acid. Prolylglycine, or L-prolylglycine is a dipeptide of proline and glycine (Pro-Gly, included in Pro-X).

See also

References
  1. GRCh38: Ensembl release 89: ENSG00000133313 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024644 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Teufel M, Saudek V, Ledig JP, Bernhardt A, Boularand S, Carreau A, et al. (February 2003). "Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase". The Journal of Biological Chemistry. 278 (8): 6521–6531. doi:10.1074/jbc.M209764200. PMID 12473676.
  6. "Entrez Gene: CNDP2 carnosine dipeptidase 2".
  7. Bauer K (1998). "Cytosol non-specific dipeptidase". In Barrett AJ, Rawlings ND, Woessner JF (eds.). Handbook of Proteolytic Enzymes. London: Academic Press. pp. 1520–1522.
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