SC
Arts and media
    
- Sim City, a city-building simulator game
 - Snapchat, a multimedia messaging app
 - Social club, a type of club.
 - Soulcalibur, fighting video game series created by Namco
 - SoundCloud, an online audio distribution platform and music sharing website
 - SportsCenter, an American daily sports-news program broadcast on ESPN
 - SportsCentre, a Canadian daily sports-news program broadcast on TSN
 - Supreme Commander, a real-time strategy video game
 
Businesses
    
- SC Paragliding, a defunct Ukrainian aircraft manufacturer
 - SCTV (Indonesia) (Surya Citra Television), an Indonesian television network
 - Shandong Airlines, IATA airline designation
 - Standard Chartered, a multinational bank company headquartered in London England
 
Education
    
- Scots College, Wellington, New Zealand
 - Southland College, Philippines
 - St. Christopher's School, Harare, Zimbabwe
 - University of South Carolina, Columbia, South Carolina, United States
- South Carolina Gamecocks, the Division I athletic program
 
 - University of Southern California, Los Angeles, California, United States
- Southern California Trojans, the Division I athletic program
 
 - Sierra Canyon School, California, United States
 
Language
    
- Sc (digraph), a combination of letters used in the spelling of some languages
 - "sc.", abbreviation for scilicet, Latin for "it is permitted to know"; See viz.
 - Sardinian language, ISO 639 language code
 - small caps
 
Government, law, and military
    
- SC convoys, a series of Allied convoys that ran during the battle of the Atlantic during World War II
 - Scheduled Castes, officially designated groups of historically disadvantaged people in India
 - Security Check, a level of security clearance in the United Kingdom
 - Post-nominal letters for Senior Counsel, or State Counsel in some countries
 - Special constable, auxiliary police constable
 - Star of Courage (Australia), an Australian decoration
 - Star of Courage (Canada), a Canadian decoration
 - Statutes of Canada, a compilation of all the federal laws passed by the Parliament of Canada since Confederation in 1867
 - The Supreme Court, the highest court in many legal jurisdictions
 - United Nations Security Council
 - Submarine chaser boat
 - Sacrosanctum Concilium one of the constitutions of the Second Vatican Council.
 - SC radar, an American-made air and surface-search radar used during World War II
 
Places
    
- Santa Catarina (state), ISO 3166-2 and Brazilian state abbreviation
 - Saint Kitts and Nevis, NATO country code
 - Secunderabad Railway Station, station code, Hyderabad, India
 - Seychelles, ISO 3166-1 alpha-2 country code
 - Sichuan, Guobiao abbreviation SC, a province of China
 - South Carolina, a state in the Eastern US
 - Southern California, a US urban area centred on Los Angeles
 - State College, a city in Pennsylvania, US
 
Science and technology
    
    Computing
    
- .sc, the country code top-level domain (ccTLD) for Seychelles
 - SC, a type of optical fiber connector, of a push-pull coupling style
 - SC (complexity), a complexity class in computer science, named after Stephen Cook
 sc.exe, a "Service Control" utility for managing Microsoft Windows services- sc (spreadsheet calculator), a text-based Unix spreadsheet program
 - PC/SC, specification for smart-card integration into computers
 - Scientific computation, a discipline in computing
 - ACM/IEEE Supercomputing Conference, known as SC or Supercomputing Conference
 
Other uses in science and technology
    
- Lexus SC, an automobile
 - sc (elliptic function), one of Jacobi's elliptic functions
 - Scandium, symbol Sc, a chemical element
 - Schmidt number (Sc), in fluid dynamics
 - × Sophrocattleya (abbreviation Sc), an orchid genus
 - Subcutaneous injection or administration, abbreviation
 - Superior colliculus, a brain region involved with eye movements
 - Clayey sand, in the Unified Soil Classification System
 - Sodium cyanide
 - Switched capacitor, an electronic circuit element implementing a filter
 
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