Wuzhishan pig

The Wuzhishan pig is a breed of inbred miniature pig created by Professor Feng Shutang[1] to be used as a model animal for medical research.

Physical description

The Wuzhishan pig grows up to a size of 50–70 cm (19.7-27.5 inches) long, and up to 30-35 kilograms (66.1-77.2 pounds) in weight.[2]

They have a black head and back, and pink legs and bellies.

Additionally, the Wuzhishan pig is often used to study the cardiovascular system in humans, due to the similarity of the pig's organs to those of a human.[3][2]

Genetic research

The full genome sequence and analysis was completed by BGI Group in 2012; the breed was successfully identified in early 2013.[4] The intellectual property rights for the breed are protected by both Chinese[5] and American patents.[6]

On May 18, 2015, the Chinese Academy of Agricultural Sciences announced that its Institute of Animal Science had agreed to transfer all breeding research to Beijing Grand Life Science & Technology Co., Ltd.,[7] which has the sole rights to breed and sell Wuzhishan pigs for commercial purposes. On November 19, 2016, the company successfully produced a litter of eight inbred piglets of F25 (the 25th generation), with an inbreeding coefficient of 0.995.

Multiple Chinese research institutions, medical schools, hospitals, and enterprises have conducted or are conducting research into the Wuzhishan pigs with an aim to establish their suitability as research models.[8][9] Additional research on the future life science and medical applications of the pigs has begun, and the initial results include the injection of embryonic germ cells into blastocysts,[10] as well as islet isolation and purification.[11]

On June 23, 2017, the Academy of Military Medical Sciences and Grand Life Science jointly announced that the PERV-pol gene-deficient WZSP have been identified and verified by systematic virology methods and whole genome sequencing.[12] Grand Life has succeed in reproducing F0/F1 PERV-noninfectious WZSP pigs that available for advanced biomedical research purposes,[13] including a series of studies under the 2017-2020 National Primary Research Programs on bio-material development, tissue-organ repair.

See also

References
  1. "中国科技网". Stdaily.com. 2015-05-27. Retrieved 2015-05-31.
  2. "Wuzhishan | Animal Genetics Training Resources". agtr.ilri.cgiar.org. Retrieved 2022-11-11.
  3. Niu, Miaomiao; Liu, Yaqian; Xiang, Lei; Zhao, Yuqiong; Yuan, Jifang; Jia, Yunxiao; Dai, Xin; Chen, Hua (March 2020). "Long‐term case study of a Wuzhishan miniature pig with diabetes". Animal Models and Experimental Medicine. 3 (1): 22–31. doi:10.1002/ame2.12098. ISSN 2576-2095. PMC 7167240. PMID 32318656.
  4. Fang, Xiaodong; et al. (December 2012). "The sequence and analysis of a Chinese pig genome". GigaScience. 1 (1): 16. doi:10.1186/2047-217X-1-16. PMC 3626506. PMID 23587058.
  5. Patent CN1502231A; 201410152868; 201410152864, etc.
  6. "US Patent Issued to Institute of Animal Science Chinese Academy of Agricultural Sciences on May 12 for "Method for Auxiliary Identification of Inbred Line of Wuzhishan Miniature Pig and Its Special Primer" (Chinese Inventors)". US Fed News Service, Including US State News. May 12, 2015. Archived from the original on 2015-09-24.
  7. "牧医所五指山小型猪近交系成果转让签约仪式在京举行_中国农业科学院". Caas.net.cn. 2015-05-21. Archived from the original on 2015-05-31. Retrieved 2015-05-31.
  8. "Journal". Journal of Agricultural Biotechnology: 849~857. 2012. doi:10.3969/j.issn.1674-7968.2012.08.001. Retrieved 2015-05-31.
  9. "近交系五指山小型猪消化器官的解剖学研究_CNKI学问". Xuewen.cnki.net. Retrieved 2015-05-31.
  10. Dong, X; Feng, Shutang; et al. (Mar 2014). "Generation of chimeric piglets by injection of embryonic germ cells from inbred Wuzhishan miniature pigs into blastocysts". Xenotransplantation. 21 (2): 140–148. doi:10.1111/xen.12077. PMID 24329557. S2CID 21964542.
  11. Jiang, X; Qian, T; Linn, T; Cao, L; Xiang, G; Wang, Y; Peng, H; Xue, P; Zhang, L; Chen, D; Yang, X (May 2012). "Islet isolation and purification from inbred Wuzhishan miniature pigs". Xenotransplantation. 19 (3): 159–165. doi:10.1111/j.1399-3089.2012.00702.x. PMID 22702467. S2CID 7099492.
  12. "我国科学家选育成功世界首例无猪内源性反转录病毒（PERV）传染性的近交系小型猪新品系 – 快讯 基因编辑 生物360 – 中文生命科学界资讯站". www.bio360.net. Archived from the original on 2017-09-07.
  13. 中国实验动物信息网，http://www.lascn.net/Item/28132.aspx
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