XAGE1D

G antigen family D member 2 is a protein that in humans is encoded by the XAGE1D gene.[3]

XAGE1B
Identifiers
AliasesXAGE1B, CT12.1, CT12.1C, CT12.1D, CT12.1E, CTP9, GAGED2, XAGE-1, XAGE1, XAGE1C, XAGE1D, X antigen family member 1E, X antigen family member 1B, XAGE1E, CT12.1b
External IDsOMIM: 300289, 300744, 300745 HomoloGene: 135786 GeneCards: XAGE1B
Orthologs
SpeciesHumanMouse
Entrez

653067

n/a

Ensembl

ENSG00000204382

n/a

UniProt

Q9HD64

n/a

RefSeq (mRNA)

n/a

RefSeq (protein)

NP_001091073
NP_001091074
NP_065144

n/a

Location (UCSC)Chr X: 52.51 – 52.52 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene generates 3 transcript variants, and one of which includes 2 transcripts generated from alternate transcription initiation sites.[3]

References
  1. GRCh38: Ensembl release 89: ENSG00000204382 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Entrez Gene: XAGE1 X antigen family, member 1".

Further reading
  • Brinkmann U, Vasmatzis G, Lee B, Pastan I (April 1999). "Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database". Cancer Research. 59 (7): 1445–8. PMID 10197611.
  • Liu XF, Helman LJ, Yeung C, Bera TK, Lee B, Pastan I (September 2000). "XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma". Cancer Research. 60 (17): 4752–5. PMID 10987281.
  • Zendman AJ, van Kraats AA, den Hollander AI, Weidle UH, Ruiter DJ, van Muijen GN (January 2002). "Characterization of XAGE-1b, a short major transcript of cancer/testis-associated gene XAGE-1, induced in melanoma metastasis". International Journal of Cancer. 97 (2): 195–204. doi:10.1002/ijc.1584. PMID 11774264. S2CID 36598913.
  • Zendman AJ, Van Kraats AA, Weidle UH, Ruiter DJ, Van Muijen GN (May 2002). "The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma". International Journal of Cancer. 99 (3): 361–9. doi:10.1002/ijc.10371. PMID 11992404. S2CID 45958151.
  • Egland KA, Kumar V, Duray P, Pastan I (May 2002). "Characterization of overlapping XAGE-1 transcripts encoding a cancer testis antigen expressed in lung, breast, and other types of cancers". Molecular Cancer Therapeutics. 1 (7): 441–50. PMID 12479262.
  • Lim JH, Kim SP, Gabrielson E, Park YB, Park JW, Kwon TK (August 2005). "Activation of human cancer/testis antigen gene, XAGE-1, in tumor cells is correlated with CpG island hypomethylation". International Journal of Cancer. 116 (2): 200–6. doi:10.1002/ijc.21007. PMID 15800911. S2CID 25575235.
  • Nakagawa K, Noguchi Y, Uenaka A, Sato S, Okumura H, Tanaka M, et al. (August 2005). "XAGE-1 expression in non-small cell lung cancer and antibody response in patients". Clinical Cancer Research. 11 (15): 5496–503. doi:10.1158/1078-0432.CCR-05-0216. PMID 16061866.
  • Sato S, Noguchi Y, Ohara N, Uenaka A, Shimono M, Nakagawa K, et al. (March 2007). "Identification of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors". Cancer Immunity. 7: 5. PMC 2935747. PMID 17335148.


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