XY
XY, or xy, or any of its variants may refer to:

Look up XY in Wiktionary, the free dictionary.
Entertainment
- XY (magazine), a gay male youth magazine that also operated a personals website
- "XY", the first episode of the eighth season of Castle TV series
- X, Y, a novel by Michael Blumlein
- X&Y, a 2005 album by Coldplay
- X+Y, 2014 British film
- X/Y, 2014 American film
- X & Y (film), 2018 Swedish film
- Xy, a member of the band Samael
- Aktenzeichen XY… ungelöst, a German television program first broadcast in 1967
- Kyle XY, American sci-fi television series
- Pokémon X and Y, 2013 role-playing video games
- Pokemon The Series: XY, 17th season of Pokémon and the first and titular season of Pokémon the Series: XY, first aired in 2013; named after the games
- XY Chelsea, a 2019 American-British documentary film about Chelsea Manning
Other uses
- (x, y)-coordinates, a system used to locate a point in two dimensions according to the cartesian coordinate system
- XY model, in physics
- XY communication problem in help desk, customer service situations
- XY sex-determination system, in many species of animal
- Male, an organism producing sperm gametes that fuse with the female gamete during sexual reproduction, typically having one X and one Y chromosome
- XY gonadal dysgenesis, also known as Swyer syndrome, a type of hypogonadism resulting in a phenotypical female with functionless gonads
- Xy (digraph), a digraph of the Romanized Popular Alphabet, used to write Hmong
- XY, aircraft registration prefix for Myanmar
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