Amoxicillin

General

• Type: Amino-Penicillin
• Dosage Forms: 250, 500, 875; 125, 200, 250, 400/5 mL
• Common Trade Names: Amoxil; Moxatag

Adult Dosing

General

• 500-875mg PO q12

Strep Pharyngitis

• 1000mg PO q24h x 10 days

Otitis Media

• 1000mg PO q8h x 10 days

Sinusitis

• 1000mg PO q8h x 10 days

Dental Abscess

• 1000mg PO x 1, then 500mg PO q8h x 3 days
• If I&D

Chlamydial Cervicitis/Urethritis

• 500mg PO q8h x 7 days
• For pregnant patients

Lyme Disease

• 500mg PO q8h x 14-21 days

Salmonella

Not 1st line treatment

• Acute
  • Immunocompetent
    • 500mg PO q8h x 3-7 days
  • Immunocompromised
    • 1000mg PO q8h x 3-14 days
• Chronic carrier
  • 1000mg PO q8h x 3 months

Typhoid Fever

Not 1st line treatment

• 50-100mg/kg/day PO divided q6-8h x 14 days
• First Dose: 12.5mg-33.3mg/kg PO x 1

Pediatric Dosing

General

• <3mo: 20-30mg/kg/day PO divided q12h
  • First Dose: 10-15mg/kg PO x 1
  • Max: 30mg/kg/day
• >3mo: 25-45mg/kg/day PO divided q12h
  • First Dose: 12.5-22.5mg/kg PO x 1
  • Max: 875mg/dose

Otitis Media

• <2 months
  • 30mg/kg/day PO divided q12h x 10 days
  • First Dose: 15mg/kg PO x 1
• 2 months - 5 years
  • 80-90mg/kg/day PO divided q12h x 10 days
  • First Dose: 40-45mg/kg PO x 1
  • Max: 1000mg/dose
• 6-12 years
  • 80-90mg/kg/day PO divided q12h x 5-10 days
  • First Dose: 40-45mg/kg/day PO x 1
  • Max: 1000mg/dose

Community Acquired Pneumonia

• 90mg/kg/day PO divided q12h x 5-10 days
• First Dose: 45mg/kg PO x 1
  • Max
    • 3 months - 4 years: 500mg/dose
    • >5 years: 4000mg/day

Strep Pharyngitis

• 50mg/kg Po q24h x 10 days
• Max: 1000mg/day

Sinusitis

• 90mg/kg/day PO divided q8-12h x 10 days
• Max: 1000mg/dose

H. pylori

• 50mg/kg/day PO divided BID x 7-14 days
• Max: 2000mg/day

Early Lyme Disease

• 50mg/kg/day PO divided q8h x 14-21 days
• First Dose: 16.6mg/kg PO x1
• Max: 500mg/dose

Salmonella (>3mo)

• 50-100mg/kg/day PO divided q8-12h
  • Acute: x 3-7 days
  • Acute Immunocompromised: 10-14 days
  • Chronic: 3 months

Typhoid Fever (>3mo)

Not 1st line treatment

• 50-100mg/kg/day PO divided q6-8h x 14 days

Special Populations

• Pregnancy Rating: B
• Lactation: Use caution
• Renal Dosing
  • Adult
  • Pediatric
• Hepatic Dosing
  • Adult
  • Pediatric

Contraindications

• Allergy to class/drug

Pharmacology

• Half-life:
• Metabolism:
• Excretion:
• Mechanism of Action:

Antibiotic Sensitivities

Group	Organism	Sensitivity
Gram Positive	Strep. Group A, B, C, G	S
	Strep. Pneumoniae	S
	Viridans strep	I
	Strep. anginosus gp	S
	Enterococcus faecalis	S
	Enterococcus faecium	I
	MSSA	R
	MRSA	R
	CA-MRSA	R
	Staph. Epidermidis	R
	C. jeikeium	R
	L. monocytogenes	S
Gram Negatives	N. gonorrhoeae	R
	N. meningitidis	S
	Moraxella catarrhalis	R
	H. influenzae	I
	E. coli	I
	Klebsiella sp	R
	E. coli/Klebsiella ESBL+	R
	E coli/Klebsiella KPC+	R
	Enterobacter sp, AmpC neg	R
	Enterobacter sp, AmpC pos	R
	Serratia sp	R
	Serratia marcescens	X1
	Salmonella sp	I
	Shigella sp	I
	Proteus mirabilis	S
	Proteus vulgaris	R
	Providencia sp.	R
	Morganella sp.	R
	Citrobacter freundii	R
	Citrobacter diversus	R
	Citrobacter sp.	R
	Aeromonas sp	R
	Acinetobacter sp.	R
	Pseudomonas aeruginosa	R
	Burkholderia cepacia	R
	Stenotrophomonas maltophilia	R
	Yersinia enterocolitica	R
	Francisella tularensis	X1
	Brucella sp.	X1
	Legionella sp.	R
	Pasteurella multocida	S
	Haemophilus ducreyi	R
	Vibrio vulnificus	X1
Misc	Chlamydophila sp	R
	Mycoplasm pneumoniae	R
	Rickettsia sp	X1
	Mycobacterium avium	X1
Anaerobes	Actinomyces	S
	Bacteroides fragilis	R
	Prevotella melaninogenica	S
	Clostridium difficile	X1
	Clostridium (not difficile)	S
	Fusobacterium necrophorum	S
	Peptostreptococcus sp.	S

Key

• S susceptible/sensitive (usually)
• I intermediate (variably susceptible/resistant)
• R resistant (or not effective clinically)
• S+ synergistic with cell wall antibiotics
• U sensitive for UTI only (non systemic infection)
• X1 no data
• X2 active in vitro, but not used clinically
• X3 active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis
• X4 active in vitro, but not clinically effective for strep pneumonia

See Also

• Antibiotics (Main)

References

Authors

Ross Donaldson