Altizide

Altizide is a thiazide diuretic. In combination with spironolactone it is sold under the brand name of Aldactacine and Aldactazine by Pfizer and other names by other companies.[1][2]

Altizide
Names
IUPAC name
(3R)-3-[(Allylsulfanyl)methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Other names
  • Althiazide
  • CB 8093
  • P 1779
  • Altizidum
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.024.541
KEGG
UNII
  • InChI=1S/C11H14ClN3O4S3/c1-2-3-20-6-11-14-8-4-7(12)9(21(13,16)17)5-10(8)22(18,19)15-11/h2,4-5,11,14-15H,1,3,6H2,(H2,13,16,17)/t11-/m1/s1 checkY
    Key: VGLGVJVUHYTIIU-LLVKDONJSA-N checkY
  • InChI=1/C11H14ClN3O4S3/c1-2-3-20-6-11-14-8-4-7(12)9(21(13,16)17)5-10(8)22(18,19)15-11/h2,4-5,11,14-15H,1,3,6H2,(H2,13,16,17)/t11-/m1/s1
    Key: VGLGVJVUHYTIIU-LLVKDONJBT
  • O=S(=O)(c1c(Cl)cc2c(c1)S(=O)(=O)N[C@@H](N2)CSC\C=C)N
  • C=CCSCC1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl
Properties
C11H14ClN3O4S3
Molar mass 383.89456
Density 1.502 g/mL
Boiling point 625.8 °C (1,158.4 °F; 898.9 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

References
  1. "Altizide". drugs.com.
  2. Dueymes, J. M (1990). "Clinical update: spironolactone and altizide as monotherapy in systemic hypertension". The American Journal of Cardiology. 65 (23): 20K–23K. doi:10.1016/0002-9149(90)91272-8. PMID 2191585.


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