Anita Corbett

Anita Hargrave Corbett is an American biochemist who is the Samuel C. Dobbs Professor in the Department of Biology at Emory University. Her research looks to understand the molecular basis for disease, the regulation of protein import and mRNA export. She is a Fellow of the American Association for the Advancement of Science and the American Society for Biochemistry and Molecular Biology.

Anita Hargrave Corbett
Alma materVanderbilt University
Colgate University
Scientific career
InstitutionsEmory University
ThesisRegulation of the catalytic cycle of topoisomerase II (1992)
InfluencesPamela Silver
WebsiteCorbett Lab

Early life and education

As a high school student, Corbett took part in the National Science Bowl. She has said that her high school chemistry teacher made her believe she could be a chemist, and encouraged her to take AP Chemistry. She was an undergraduate student at Colgate University,[1] where she became interested in biochemistry, and studied the activation and inhibition of bovine carbonic anhydrase.[2] Corbett was a doctoral researcher at Vanderbilt University,[3] where she studied the regulation of topoisomerase II.[4] She moved to Harvard Medical School as a postdoctoral researcher with Pamela Silver.[5]

Research and career

In 2003, Corbett was the first woman to be tenured in the Emory University School of Medicine.[3] Her research considers the regulation of biological processes, including the import of proteins and export of mRNA. She studies these processes using model systems of yeast, drosophila and mice.[6][7] It is well understood that disease is linked to mutations in genes encoding structural RNA exosome subunits.[3] Corbett linked mutations in one particular subunit, EXOSC5, to poor clinical outcomes.[8] She has extensively investigated RNA-binding proteins, which are involved with various stages of gene expression.[9]

Awards and honors

Selected publications
  • Allison Lange; Ryan E. Mills; Christopher J Lange; Murray Stewart; Scott E Devine; Anita H Corbett (14 December 2006). "Classical nuclear localization signals: definition, function, and interaction with importin alpha". Journal of Biological Chemistry. 282 (8): 5101–5105. doi:10.1074/JBC.R600026200. ISSN 0021-9258. PMC 4502416. PMID 17170104. Wikidata Q34591163.
  • Debashish Ray; Hilal Kazan; Kate B Cook; et al. (1 July 2013). "A compendium of RNA-binding motifs for decoding gene regulation". Nature. 499 (7457): 172–177. doi:10.1038/NATURE12311. ISSN 1476-4687. PMC 3929597. PMID 23846655. Wikidata Q34357005.
  • David S Goldfarb; Anita H Corbett; D Adam Mason; Michelle T Harreman; Stephen A. Adam (1 September 2004). "Importin alpha: a multipurpose nuclear-transport receptor". Trends in Cell Biology (in English and English). 14 (9): 505–514. doi:10.1016/J.TCB.2004.07.016. ISSN 0962-8924. PMID 15350979. Wikidata Q35879618.

References
  1. "Anita H. Corbett, PhD". biology.emory.edu. Retrieved 2023-05-02.
  2. Rowlett, R S; Gargiulo, N J; Santoli, F A; Jackson, J M; Corbett, A H (1991-01-15). "Activation and inhibition of bovine carbonic anhydrase III by dianions". Journal of Biological Chemistry. 266 (2): 933–941. doi:10.1016/S0021-9258(17)35263-8. ISSN 0021-9258.
  3. "Corbett goes the extra mile to support young scientists". www.asbmb.org. Retrieved 2023-05-02.
  4. "Regulation of the catalytic cycle of topoisomerase II | WorldCat.org". www.worldcat.org. Retrieved 2023-05-02.
  5. "Nature Awards give mentors the recognition, funding, and 'street cred' they need | For Researchers | Springer Nature". www.springernature.com. Retrieved 2023-05-02.
  6. "Professor Anita H. Corbett". www.rnasociety.org. Retrieved 2023-05-02.
  7. Corbett, Anita H. (2015-04-01). "A long and winding road to the RNA world". RNA. 21 (4): 590–591. doi:10.1261/rna.049841.115. ISSN 1355-8382. PMID 25780152.
  8. Slavotinek, Anne; Misceo, Doriana; Htun, Stephanie; Mathisen, Linda; Frengen, Eirik; Foreman, Michelle; Hurtig, Jennifer E.; Enyenihi, Liz; Sterrett, Maria C.; Leung, Sara W.; Schneidman-Duhovny, Dina; Estrada-Veras, Juvianee; Duncan, Jacque L.; Haaxma, Charlotte A.; Kamsteeg, Erik-Jan (2020-08-03). "Biallelic variants in the RNA exosome gene EXOSC5 are associated with developmental delays, short stature, cerebellar hypoplasia and motor weakness". Human Molecular Genetics. 29 (13): 2218–2239. doi:10.1093/hmg/ddaa108. ISSN 1460-2083. PMC 7399534. PMID 32504085.
  9. "Anita Corbett". biology.emory.edu. Retrieved 2023-05-02.
  10. "Laney Graduate School announces Eleanor Main Graduate Mentor Awards | Emory University | Atlanta GA". news.emory.edu. Retrieved 2023-05-02.
  11. "Emory faculty named 2022 fellows of the American Association for the Advancement of Science | Emory University | Atlanta GA". news.emory.edu. Retrieved 2023-05-02.
  12. "2022 ASBMB fellows named". www.asbmb.org. Retrieved 2023-05-02.
  13. "2022 RNA Society Award for Excellence in Inclusive Leadership". www.rnasociety.org. Retrieved 2023-05-02.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.