Asialoglycoprotein

If terminal sialic acid residues are removed from glycoproteins, the resulting proteins are known as asialoglycoproteins.[1][2]

The exposure of the subterminal galactose residues results in rapid clearance of the glycoproteins from the circulation through hepatocyte asialoglycoprotein receptors on Kuppfer cells.

References

  1. Gross, Hans Jürgen; Brossmer, Reinhard (1987-06-01). "N-Acetyl-4-deoxy-d-neuraminic acid is activated and transferred on to asialoglycoprotein". Glycoconjugate Journal. 4 (2): 145–156. doi:10.1007/BF01049452. ISSN 1573-4986. S2CID 7911178.
  2. Regoeczi, E.; Chindemi, P. A. (1981-01-01). "The net weight of the rabbit liver and its relevance for asialoglycoprotein clearance". Growth. 45 (1): 19–28. ISSN 0017-4793. PMID 7227848.


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