Aviv Regev

Aviv Regev (born July 11, 1971)[1] is a computational biologist and systems biologist and Executive Vice President and Head of Genentech Research and Early Development in Genentech/Roche.[4] She is a core member (on leave) at the Broad Institute of MIT and Harvard and professor (on leave) at the Department of Biology of the Massachusetts Institute of Technology.[5] Regev is a pioneer of single cell genomics and of computational and systems biology of gene regulatory circuits. She founded and leads the Human Cell Atlas project,[6] together with Sarah Teichmann.

Aviv Regev
Regev at the Intelligent Systems for Molecular Biology conference in 2017
Born (1971-07-11) July 11, 1971[1]
Alma materTel Aviv University (M.Sc., Ph.D.)
Awards
Scientific career
FieldsBioinformatics
Computational Biology
Institutions
Doctoral advisorEva Jablonka
Ehud Shapiro
Websitewww.broadinstitute.org/bios/aviv-regev

Education

Regev studied at the Adi Lautman Interdisciplinary Program for Outstanding Students of Tel Aviv University, where she completed her Ph.D. under the supervision of Eva Jablonka[7] and Ehud Shapiro.[8]

Career and research

In 2020, Regev became the Head and Executive Vice President of Genentech Research and Early Development, based in South San Francisco, and a member of the extended Corporate Executive Committee of Roche.[9][10] Previously, she was a Core Institute Member (now on leave), Chair of the Faculty, Founding Director of the Klarman Cell Observatory and co-Director Cell Circuits Program at the Broad Institute of MIT and Harvard. She was also a professor in the Department of Biology at the Massachusetts Institute of Technology (now on leave), as well as an Investigator at the Howard Hughes Medical Institute. Regev's research[11] includes work on gene expression[12][13] (with Eran Segal and David Botstein), and the use of π-calculus to represent biochemical processes.[14][15][16] Regev's team has been a leading pioneer of single-cell genomics experimental and computational methods.[17] In 2014, she pitched the idea of the creation of Human Cell Atlas,[18] a project to describe all cell types in the human body. Regev founded the Human Cell Atlas together with Sarah Teichmann along with collaborators all over the world.

Single Cell Genomics

Regev's lab pioneered the development and application of many of the key experimental and computational advances for single cell and spatial genomics, especially single cell RNA-Seq (scRNA-seq).

Awards and honors

Regev is a fellow of the International Society of Computational Biology (ISCB) (2017),[19] a Helmholtz Fellow (2020),[20] and a fellow of the American Association for Cancer Research (AACR) (2021).[21] She is a member of the US National Academy of Sciences (NAS, elected 2019)[22] and of the US National Academy of Medicine (NAM, elected 2020).[23]

  • Regev was awarded the Overton Prize in 2008 for "outstanding accomplishment to a scientist in the early to mid stage of his or her career".[2]
  • In 2008, she was also awarded the NIH Director's Pioneer Award.[24][25]
  • She has also been awarded the Burroughs Wellcome Fund Career Award.[26]
  • Earl and Thressa Stadtman Scholar Award from the American Society of Biochemistry and Molecular Biology (ASBMB) (2014)[27]
  • She was awarded the ISCB Innovator Award in 2017.[3][28]
  • In 2017, she was awarded a Paul Marks Prize for Cancer Research.[29]
  • McCormick Lecture, Stanford University (2018)[30]
  • Harvey Lecture, Harvey Society, New York (2018)[31]
  • Weatherall Lecture, University Oxford, UK (2018)[32]
  • She also served on the Life Sciences jury for the Infosys Prize in 2018.
  • She was elected a member of the National Academy of Sciences (NAS) in 2019.[33]
  • FASEB Excellence in Science Mid-Career Investigator Award (2019)[34]
  • She was awarded the 25th Keio Medical Science Prize in 2020.[35]
  • Jonathan Kraft Prize from Massachusetts General Hospital (2020)[36]
  • Mendel Lecture, European Society of Human Genetics (2020)[37]
  • Lurie Prize from the Foundation for the NIH (FNIH) (2020)[38]
  • AACR-Irving Weinstein Foundation Distinguished Lecture (2021)[39]
  • 25th Keio Medical Science Prize (2020)[40]
  • Vanderbilt Prize (2021)[41]
  • James Prize in Science and Technology Integration, National Academy of Sciences (2021)[42]
  • Ernst Schering Prize (2021)[43]
  • Honorary doctorate, ETH Zurich (2021)[44]
  • Nakasone Award from the Human Frontiers Science Program (2022)[45]
  • Anderson Lecture, University of Virginia, 2022[46]
  • Elected to the American Academy of Arts and Sciences, 2022[47]

References
  1. "Aviv Regev" (PDF). broadinstitute.org. Archived from the original (PDF) on 16 November 2017. Retrieved 2 December 2021.
  2. Sansom, C.; Morrison Mckay, B. J. (2008). Bourne, Philip E. (ed.). "ISCB Honors David Haussler and Aviv Regev". PLOS Computational Biology. 4 (7): e1000101. Bibcode:2008PLSCB...4E0101S. doi:10.1371/journal.pcbi.1000101. PMC 2536508. PMID 18795145. open access
  3. Fogg, Christiana N.; Kovats, Diane E.; Berger, Bonnie (2017). "2017 ISCB Innovator Award: Aviv Regev". PLOS Computational Biology. 13 (6): e1005558. Bibcode:2017PLSCB..13E5558F. doi:10.1371/journal.pcbi.1005558. ISSN 1553-7358. PMC 5493285. PMID 28665936. open access
  4. GENENTECH EXECUTIVE COMMITTEE, accessed August 6, 2020.
  5. "Aviv Regev at MIT". biology.mit.edu.
  6. Nowogrodzki, Anna (5 July 2017). "How to build a human cell atlas". Nature. 547 (7661): 24–26. Bibcode:2017Natur.547...24N. doi:10.1038/547024a. PMID 28682347. S2CID 211067156.
  7. Regev, A.; Lamb, M. J.; Jablonka, E. (1998). "The Role of DNA Methylation in Invertebrates: Developmental Regulation or Genome Defense?". Molecular Biology and Evolution. 15 (7): 880. doi:10.1093/oxfordjournals.molbev.a025992. ISSN 0737-4038.
  8. Regev, A.; Shapiro, E. (2002). "Cellular abstractions: Cells as computation". Nature. 419 (6905): 343. Bibcode:2002Natur.419..343R. doi:10.1038/419343a. PMC 3842595. PMID 12353013. closed access
  9. Taylor, Nick Paul (May 11, 2020). "Genentech lures Regev from Broad Institute to lead research and early development". fiercebiotech.com. Retrieved 25 May 2020.
  10. "Changes to the Roche Enlarged Corporate Executive Committee" (Press release). Basel, Switzerland: F. Hoffmann-La Roche Ltd. globenewswire. May 11, 2020. Retrieved 2020-05-25.
  11. Search Results for author Regev A on PubMed.
  12. Segal, E.; Shapira, M.; Regev, A.; Pe'er, D.; Botstein, D.; Koller, D.; Friedman, N. (2003). "Module networks: Identifying regulatory modules and their condition-specific regulators from gene expression data". Nature Genetics. 34 (2): 166–176. doi:10.1038/ng1165. PMID 12740579. S2CID 6146032.
  13. Segal, E.; Friedman, N.; Koller, D.; Regev, A. (2004). "A module map showing conditional activity of expression modules in cancer". Nature Genetics. 36 (10): 1090–1098. doi:10.1038/ng1434. PMC 2271138. PMID 15448693. closed access
  14. Regev, A.; Silverman, W.; Shapiro, E. (2001). "Representation and simulation of biochemical processes using the pi-calculus process algebra". Pacific Symposium on Biocomputing: 459–470. doi:10.1142/9789814447362_0045. ISBN 978-981-02-4515-3. PMID 11262964.
  15. Priami, C.; et al. (2001). "Application of a stochastic name-passing calculus to representation and simulation of molecular processes" (PDF). Information Processing Letters. 80: 25–31. doi:10.1016/S0020-0190(01)00214-9. closed access
  16. Study provides insight into regenerative potential of prostate gland, News Medical, accessed May 4, 2020.
  17. "Aviv Regev". HHMI.org. Retrieved 2020-05-11.
  18. The Human Cell Atlas - Aviv Regev, retrieved 2022-05-30
  19. "2017 ISCB Innovator Award: Aviv Regev". www.iscb.org. Retrieved 2022-03-14.
  20. "Event – Helmholtz Zentrum München". www.helmholtz-munich.de. Retrieved 2022-03-14.
  21. "Aviv Regev, PhD, FAACR | Scientific Awards | AACR". American Association for Cancer Research (AACR). Retrieved 2022-03-14.
  22. "Aviv Regev". www.nasonline.org. Retrieved 2022-03-14.
  23. "National Academy of Medicine Elects 100 New Members". National Academy of Medicine. 2020-10-19. Retrieved 2022-03-14.
  24. "Three faculty win '08 NIH Pioneer Awards". MIT News | Massachusetts Institute of Technology. Retrieved 2022-03-06.
  25. 2008 NIH Director's Pioneer Award
  26. Dynamic single-cell imaging of direct reprogramming reveals an early specifying event - Nature Biotechnology: Aviv Regev, Ph.D. - Career Awards at the Scientific Interface; Ab initio reconstruction of cell type–specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs - Nature Biotechnology: Aviv Regev, Ph.D. - Career Awards at the Scientific Interface.
  27. "Regev recognized for rigorous integration of experimental and computational approaches". www.asbmb.org. Retrieved 2022-03-14.
  28. "February 09, 2017: ISCB Announces 2017 Award Recipients". iscb.org. Retrieved 10 February 2017.
  29. "2017 Prize Winners". Memorial Sloan Kettering Cancer Center. Retrieved 12 December 2017.
  30. "MIT's Aviv Regev to present annual McCormick Lecture Feb. 1". News Center (in Samoan). Retrieved 2022-03-14.
  31. "The Harvey Society: Series 113, Lecture 5". harveysociety.org. Retrieved 2022-03-14.
  32. "Weatherall Lectures — MRC Weatherall Institute of Molecular Medicine". www.imm.ox.ac.uk. Retrieved 2022-03-14.
  33. "2019 NAS Election". nasonline.org. Retrieved 30 April 2019.
  34. "Past Recipients". www.faseb.org. Retrieved 2022-03-14.
  35. "Award Ceremony for the 25th Keio Medical Science Prize". keio.ac.jp. Retrieved 22 December 2020.
  36. "Kraft Prize Symposium". Massachusetts General Hospital. Retrieved 2022-03-14.
  37. Wimmer, Doris. "Aviv Regev". ESHG Conference 2020. Retrieved 2022-03-14.
  38. "2020 FNIH Lurie Prize in Biomedical Sciences Winner Pioneered Innovative Techniques to Shed New Light on Human Health | The Foundation for the National Institutes of Health". fnih.org. Retrieved 2022-03-18.
  39. "Aviv Regev, PhD, FAACR | Scientific Awards | AACR". American Association for Cancer Research (AACR). Retrieved 2022-03-18.
  40. "Announcement of the 25th Keio Medical Science Prize - News - Keio University Medical Science Fund". www.ms-fund.keio.ac.jp. Retrieved 2022-03-18.
  41. Snyder, Bill. "Regev receives Vanderbilt Prize in Biomedical Science". Vanderbilt University. Retrieved 2022-03-18.
  42. "James Prize in Science and Technology Integration". www.nasonline.org. Retrieved 2022-03-18.
  43. "Ernst Schering Prize 2021 – Schering Stiftung". Retrieved 2022-03-18.
  44. phone +41 61 387 33 00, Work; contacts V-Card (vcf, 1kb). "Pioneer in bioinformatics receives ETH Honorary doctorate". bsse.ethz.ch. Retrieved 2022-03-18.
  45. "Press Release - 2022 HFSP Nakasone Award".
  46. "The Events Calendar".{{cite web}}: CS1 maint: url-status (link)
  47. "New Members". American Academy of Arts & Sciences. Retrieved 2022-05-30.
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