Gen V

• Jaz Sinclair as Marie Moreau, a blood manipulative with a tragic past.
• Chance Perdomo as Andre Anderson, a popular metal bender.
• Lizze Broadway as Emma Shaw, a YouTuber that can shrink to 0.5 inches.
• Maddie Phillips as Cate Dunlap, a mind empath.
• Derek Luh and London Thor as Jordan, a gender-shifter.
• Asa Germann
• Shelley Conn

• Patrick Schwarzenegger as Golden Boy, a popular student and fire manipulator.
• Sean Patrick Thomas as Polarity
• Marco Pigossi as Doctor Edison Cardosa
• Jason Ritter
• Alexander Calvert[7]
• Clancy Brown as Richard "Rich Brink" Brinkerhoff[8][9]

• Jessie T. Usher as Reggie Franklin / A-Train
• Colby Minifie as Ashley Barrett
• P. J. Byrne as Adam Bourke
• Jensen Ackles as Ben / B.C.L. RED / Soldier Boy[10]

On September 20, 2020, a spin-off of The Boys was announced, with Craig Rosenberg writing and executive producing the series with Eric Kripke, Seth Rogen, Evan Goldberg, James Weaver, Neal H. Moritz, Pavun Shetty, Michaela Starr, Garth Ennis, Darick Robertson, Sarah Carbiener, Erica Rosbe, Aisha Porter-Christie, Judalina Neira, and Zak Schwartz.[6] On September 27, 2021, Amazon gave the order for the series and Michele Fazekas and Tara Butters were set as showrunners and executive producers of the series.[11] On October 2, 2020, Kripke stated the Hunger Games-inspired series would focus on the G-Men team mentioned in the first season of The Boys, originally created as a parody of Marvel Comics' X-Men for the fourth volume of Ennis' and Robertson's comic book series: "We Gotta Go Now", from which the series is "loosely inspired".[12]

On January 5, 2023, it was announced that a writing room for a potential second season will soon come together, which will be led by Michele Fazekas who also has become sole showrunner after Tara Butters has taken a break from work.[13]

On March 11, 2021, Lizze Broadway and Jaz Sinclair were cast in the series.[14][15] On March 19, Shane Paul McGhie, Aimee Carrero, and Maddie Phillips were cast in the series.[16] On April 15, 2021, Reina Hardesty was cast in the series.[17] On March 10, 2022, Carrero and McGhie exited the series.[18] A few days later, Chance Perdomo joined the main cast in a recasting, replacing McGhie.[19] On April 25, 2022, Hardesty left the series.[20] On May 9, 2022, London Thor was cast to replace Hardesty. Derek Luh, Asa Germann, and Shelley Conn also joined the cast as series regulars.[21] Two days later, Patrick Schwarzenegger, Sean Patrick Thomas, and Marco Pigossi were cast in recurring capacities.[22] In November 2022, Clancy Brown joined the cast as Richard "Rich Brink" Brinkerhoff.[8][9] In December 2022, Jessie T. Usher, Colby Minifie, and P. J. Byrne were confirmed to be reprising their roles from The Boys, in guest appearances, as Reggie Franklin / A-Train, Ashley Barrett, and Adam Bourke, respectively.[23]

Filming began at the University of Toronto Mississauga campus in May 2022 and the Claireville Conservation Area, Brampton in July, intended for an October wrap, under the working title of The Boys Presents: Varsity.[24] In July 2022, it was announced that the series would officially be titled Gen V.[1] In September 2022, members of the cast announced on social media that production had wrapped.[25]