Meenakshi Ponnunga

• Mokshitha Pai [4] (2022)/ Soundarya Reddy [5] (2022-present) as Shakthi – Meenakshi and Needhimani's second daughter; Yamuna's younger sister; Durga's elder sister; Vetri's love interest and wife; Ranganayagi's daughter-in-law
• Archana[6] (2022-2023)[7] as Meenakshi – Needhimani's first wife; Yamuna, Shakthi and Durga's mother; Karthik and Vetri's mother-in-law
• Aryan[8] as Vetri – Ranganayaki's son; Saranya's brother; Pooja's ex-fiancé; Shakthi's husband

• Gayathri Yuvraj[9] as Yamuna – Meenakshi and Needhimani's first daughter; Shakthi and Durga's elder sister; Karthik's love interest and wife
• Pranika Dhakshu as Durga – Meenakshi and Needhimani's last daughter; Shakthi and Yamuna's younger sister
• Sasilaya as Ranganayagi – Vetri and Sunganya's mother; Shakthi and Ashok's mother-in-law
• Anandmouli as Ranganayagi's husband
• Subathira as Pushpa − Needhimani's second wife; Shanmugam's mother
• Prabhakaran as Needhimani – Meenakshi and Pushpa's husband; Yamuna, Shakthi, Durga and Shanmugam's father; Karthik and Vetri's father-in-law
• Suganya as Saranya – Ranganayagi's daughter; Vetri's sister; Ashok's wife
• Hema Dayal as Pooja – Vetri's ex-fianceè
• Sudharsanam / Vishnukanth as Karthik – Kokila's son; Yamuna's husband
• Aarthi Ramkumar as Kokila – Karthik's mother
• Singaraja as Kokila's husband and Karthik's mother
• Deepa Shankar as Shantha – Meenakshi's friend and maid
• Vigneshwaran as Ashok – Saranya's husband
• Thidiyan as Thidiyan – Vetri's friend
• Tom Frank as Vetri's friend
• Sanjay as Shanmugam – Needhimani and Pushpa's son

After the ending of the longest running Zee Tamil TV drama Sembaruthi, its Production Company Insidues Media decide to produce Meenakshi Ponnunga. The series was directed by Neethane Enthan Ponvasantham fame L. Muthukumaraswamy.

Actress Archana was signed to portray the titular role Meenakshi in her first television debut. She quit the serial in April 2023 due to being unsatisfied with the storyline. Mokshitha Pai,[11] was selected to play the role Shakthi, by marking her debut in Tamil Television Network but later was replaced by Soundarya Reddy in November 2022 who also made her debut in Tamil Television Network. Aryan was selected to play the character Vetri.[12] Tamil Motivational speaker Sasilaya, made her first acting in the role of Renganayagi.[13]

Zee Tamil was promoted their new three fictions Maari, Amudhavum Annalakshmiyum and including this series by making advertisement with actress Sneha, Saranya Ponvannan and Sangeetha with the slogan "Vanga Paarkalaam Ithu Namma Time" and this promo released on 26 June 2022.[14]