Pyridinylpiperazine
1-(2-Pyridinyl)piperazine is a chemical compound and piperazine derivative. Some derivatives of this substance are known to act as potent and selective α2-adrenergic receptor antagonists, such as 1-(3-fluoro-2-pyridinyl)piperazine.[1]
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| Preferred IUPAC name
1-(Pyridin-2-yl)piperazine | |
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3D model (JSmol) |
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| ECHA InfoCard | 100.047.458 |
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| Properties | |
| C9H13N3 | |
| Molar mass | 163.22 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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A few pyridinylpiperazine derivatives are drugs, including:
- ABT-724
- AR234960
- Azaperol [2804-05-9]
- Azaperone — antipsychotic
- Atevirdine — antiretroviral
- BRN 0563047 [59215-20-2] "Stimulating dopaminerginic activity":[2] Journal Ref (Cmp XVIII):[3]
- CP-226,269
- Delavirdine — antiretroviral
- Mirtazapine — antidepressant
- MLS1547 [315698-36-3]
- Revenast [85673-87-6]
- UMB38[4]
- XH-148
References
- Saari WS, Halczenko W, King SW, et al. (December 1983). "Pyridinylpiperazines, a new class of selective alpha 2-adrenoceptor antagonists". Journal of Medicinal Chemistry. 26 (12): 1696–701. doi:10.1021/jm00366a007. PMID 6139479.
- Claude Dumont & Claude Oberlander, U.S. Patent 4,112,093 (1978 to Sanofi Aventis France).
- Boissier, J. R., Ratouis, R., Dumont, C. (September 1963). "Synthesis and Pharmacological Study of New Piperazine Derivatives. I. Benzylpiperazines". Journal of Medicinal Chemistry. 6 (5): 541–544. doi:10.1021/jm00341a016. PMID 14173578.
- Motel, W. C., Healy, J. R., Viard, E., Pouw, B., Martin, K. E., Matsumoto, R. R., Coop, A. (December 2013). "Chlorophenylpiperazine analogues as high affinity dopamine transporter ligands". Bioorganic & Medicinal Chemistry Letters. 23 (24): 6920–6922. doi:10.1016/j.bmcl.2013.09.038. PMC 3919026. PMID 24211020.
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