Sodium ferulate

Sodium ferulate, the sodium salt of ferulic acid, is a compound used in traditional Chinese medicine thought to be useful for treatment of cardiovascular and cerebrovascular diseases and to prevent thrombosis, although there is no high-quality clinical evidence for such effects. It is found in the root of Angelica sinensis. As of 2005, it was under preliminary clinical research in China.[1] Ferulic acid can also be extracted from the root of the Chinese herb Ligusticum chuanxiong.[2]

Sodium ferulate
Names
Preferred IUPAC name
Sodium (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
UNII
  • InChI=1S/C10H10O4.Na/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13;/h2-6,11H,1H3,(H,12,13);/q;+1/p-1/b5-3+; checkY
    Key: NCTHNHPAQAVBEB-WGCWOXMQSA-M checkY
  • InChI=1/C10H10O4.Na/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13;/h2-6,11H,1H3,(H,12,13);/q;+1/p-1/b5-3+;
    Key: NCTHNHPAQAVBEB-OLHRVHTCBT
  • [Na+].[O-]C(=O)\C=C\c1cc(OC)c(O)cc1
Properties
C10H9NaO4
Molar mass 216.17 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Infobox references

Kraft Foods patented the use of sodium ferulate to mask the aftertaste of the artificial sweetener acesulfame potassium.[3]

References
  1. Wang, B. H.; Ou-Yang, J. P. (2005). "Pharmacological Actions of Sodium Ferulate in Cardiovascular System". Cardiovascular Drug Reviews. 23 (2): 161–172. doi:10.1111/j.1527-3466.2005.tb00163.x. PMID 16007232.
  2. Wang, W.; Sun, Y. (2008). "Ultrasonic Extraction of Ferulic Acid from Ligusticum chuanxiong". Journal of the Chinese Institute of Chemical Engineers. 39 (6): 653–656. doi:10.1016/j.jcice.2008.05.012.
  3. US patent 5336513, Riemer, J. A., "Bitterness Inhibitors", issued 1994-08-09, assigned to Kraft General Foods (expired in 2006 due to non-payment of fees)
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