1450s
| Millennium: | 2nd millennium | 
| Centuries: | 14th century – 15th century – 16th century | 
| Decades: | 1420s 1430s 1440s – 1450s – 1460s 1470s 1480s | 
| Years: | 1450 1451 1452 1453 1454 1455 1456 1457 1458 1459 | 
| Categories: | Births – Deaths – Architecture Establishments – Disestablishments  | 
Events
    
- Fall of Constantinople (now called Istanbul).
 - France wins the Hundred Years' War against England.
 - The first printing press is made in Europe by Johann Gutenberg.
 - The Gutenberg Bible is the first book printed with movable type.
 - Siege of Belgrade.
 - War of the Roses starts.
 
Births
    
- Queen Isabella of Castile
 - Christopher Columbus, Italian sailor
 - Leonardo da Vinci, Italian inventor
 - Girolamo Savonarola, Italian religious reformer
 - Ferdinand II of Aragon
 
Deaths
    
- Murad II, Ottoman Sultan
 - John Kemp, Archbishop of Canterbury
 
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