Thiamine

Thiamine
	Skeletal formula and ball-and-stick model of the cation in thiamine
Clinical data
Pronunciation	/ˈθaɪ.əmɪn/ THY-ə-min
Synonyms	Vitamin B1, aneurine, thiamin
AHFS/Drugs.com	Monograph
License data	US DailyMed: Thiamine; US FDA: Thiamine;
Routes of; administration	by mouth, IV, IM[1]
Drug class	vitamin
ATC code	cation: A11DA01 (WHO) ;
Legal status
Legal status	US: OTC ;
Pharmacokinetic data
Bioavailability	3.7% to 5.3% Template:Medical citation needed
Elimination half-life	1.8d[2]
Identifiers
	IUPAC name 2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol;
CAS Number	cation: 70-16-6 ; 67-03-8 (Cl-.HCl); Cl- salt: 59-43-8 ;
PubChem CID	cation: 1130;
PubChem SID	Cl- salt: 6042;
DrugBank	cation: DB00152;
ChemSpider	cation: 1098;
UNII	cation: 4ABT0J945J; Cl- salt: X66NSO3N35 ;
KEGG	cation: C00378;
ChEBI	cation: CHEBI:18385;
ChEMBL	cation: ChEMBL1547;
Chemical and physical data
Formula	C12H17N4OS+
Molar mass	265.36 g·mol−1
3D model (JSmol)	cation: Interactive image;
	SMILES cation: Cc2ncc(C[n+]1csc(CCO)c1C)c(N)n2;
	InChI cation: InChI=1S/C12H17N4OS/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15)/q+1 ; Key:JZRWCGZRTZMZEH-UHFFFAOYSA-N;

Thiamine (or thiamin) is vitamin B₁. It is a water-soluble vitamin of the B complex. Its phosphate derivatives take part in many cellular processes. Thiamine pyrophosphate (TPP) is a coenzyme in the catabolism of sugars and amino acids.

also it can be found in Food and Manufactured Dietary supplements also in Medications[1][3] Foods that provide Thiamine include whole grains, Legume[1]

Lack of thiamine causes beriberi.

References

"Thiamin Fact Sheets for Health Professionals". Office of Dietary Supplements. 11 February 2016. Archived from the original on 30 December 2016. Retrieved 30 December 2016.
Royer-Morrot MJ, Zhiri A, Paille F, Royer RJ (1992). "Plasma thiamine concentrations after intramuscular and oral multiple dosage regimens in healthy men". European Journal of Clinical Pharmacology. 42 (2): 219–22. doi:10.1007/BF00278489. PMID 1618256. S2CID 19924442.
"Thiamine: MedlinePlus Drug Information". medlineplus.gov. Retrieved 30 April 2018.

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[NIH2016-1] "Thiamin Fact Sheets for Health Professionals". Office of Dietary Supplements. 11 February 2016. Archived from the original on 30 December 2016. Retrieved 30 December 2016.

[pmid1618256-2] Royer-Morrot MJ, Zhiri A, Paille F, Royer RJ (1992). "Plasma thiamine concentrations after intramuscular and oral multiple dosage regimens in healthy men". European Journal of Clinical Pharmacology. 42 (2): 219–22. doi:10.1007/BF00278489. PMID 1618256. S2CID 19924442.

[medline-3] "Thiamine: MedlinePlus Drug Information". medlineplus.gov. Retrieved 30 April 2018.