CFU-GM
CFU-GM (Colony Forming Unit–Granulocyte–Macrophage[lower-alpha 1]), also known as granulocyte–macrophage progenitor (GMP), is a colony forming unit. It is derived from CFU-GEMM. It is the precursor for monoblasts and myeloblasts. Production is stimulated by granulocyte macrophage colony-stimulating factor (GM-CSF).
| CFU-GM | |
|---|---|
 Lineage. Captions in Polish, but "GMP" visible near bottom center. | |
| Details | |
| Gives rise to | Monoblasts and myeloblasts |
| Location | Bone marrow |
| Function | colony forming unit |
| Identifiers | |
| MeSH | D055014 |
| TH | H2.00.04.3.02009 |
| Anatomical terms of microanatomy | |
Granulocytes
There is some controversy over which granulocytes derive from CFU-GM.
- There is little disagreement that neutrophils come from CFU-GM.
- Some sources state that basophils also derive from CFU-GM, but that eosinophils come from "CFU-Eos".[2]
- Other sources state that basophils do not derive from CFU-GM, but from a distinct CFU, titled "CFU-Baso".[3]
Notes
- The "GM" can also stand for "Granulocyte-Monocyte".[1]
References
- "Hem I WBC Morphology and Physiology". Archived from the original on December 25, 2008. Retrieved 2008-12-30.
- Ganong, William F.; McPhee, Stephen J.; Lingappa, Vishwanath R. (2005). Pathophysiology of Disease: An Introduction to Clinical Medicine (Lange). McGraw-Hill Medical. p. 107. ISBN 0-07-144159-X.
- Rudolph, Colin David (2003). Rudolph's pediatrics. New York: McGraw-Hill, Medical Pub. Division. p. 1563. ISBN 0-8385-8285-0.
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