Dazopride

Dazopride (AHR-5531) is an antiemetic and gastroprokinetic agent of the benzamide class which was never marketed.[1][2][3][4][5] It acts as a 5-HT3 receptor antagonist and 5-HT4 receptor agonist.[3][4][6] In addition to its gastrointestinal effects, dazopride facilitates learning and memory in mice.[7]

Dazopride
Clinical data
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • In general: uncontrolled
Identifiers
  • 4-amino-5-chloro-N-(1,2-diethylpyrazolidin-4-yl)-2-methoxybenzamide
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC15H23ClN4O2
Molar mass326.83 g·mol−1

See also

References
  1. Grant SC, Kris MG, Gralla RJ, Clark RA, Tyson LB (1993). "Dose-ranging evaluation of the substituted benzamide dazopride when used as an antiemetic in patients receiving anticancer chemotherapy". Cancer Chemotherapy and Pharmacology. 31 (6): 442–444. doi:10.1007/bf00685032. PMID 8453682. S2CID 23122385.
  2. Alphin RS, Proakis AG, Leonard CA, Smith WL, Dannenburg WN, Kinnier WJ, et al. (May 1986). "Antagonism of cisplatin-induced emesis by metoclopramide and dazopride through enhancement of gastric motility". Digestive Diseases and Sciences. 31 (5): 524–529. doi:10.1007/bf01320319. PMID 3698769. S2CID 6571531.
  3. Costall B, Domeney AM, Gunning SJ, Kelly ME, Naylor RJ, Nohria V, et al. (July 1987). "The action of dazopride to enhance gastric emptying and block emesis". Neuropharmacology. 26 (7A): 669–677. doi:10.1016/0028-3908(87)90227-9. PMID 3114664. S2CID 25143512.
  4. Costall B, Domeney AM, Naylor RJ, Tattersall FD (September 1987). "Emesis induced by cisplatin in the ferret as a model for the detection of anti-emetic drugs". Neuropharmacology. 26 (9): 1321–1326. doi:10.1016/0028-3908(87)90094-3. PMID 2890117. S2CID 24621209.
  5. Ganellin CR, Triggle DJ (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9.
  6. Villalón CM, den Boer MO, Heiligers JP, Saxena PR (January 1991). "Further characterization, by use of tryptamine and benzamide derivatives, of the putative 5-HT4 receptor mediating tachycardia in the pig". British Journal of Pharmacology. 102 (1): 107–112. doi:10.1111/j.1476-5381.1991.tb12140.x. PMC 1917868. PMID 2043916.
  7. Montgomery SA, Halbreich U (2000). Pharmacotherapy for mood, anxiety, and cognitive disorders. Washington, DC: American Psychiatric Press. ISBN 0-88048-885-9.
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