Isothipendyl

Isothipendyl is a 1st generation H1 antagonist (antihistamine) and anticholinergic used as an antipruritic.[1] In the 2020s, at least, it is rarely used in the first line relief of allergies due to the anticholinergic side effect of somnolence but does have some limited use through topical application in the relief of insect bites and related itching (pruritus).

Isothipendyl
Skeletal formula
Ball-and-stick model of isothipendyl
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • N,N-dimethyl-1-(10H-pyrido[3,2-b][1,4]benzothiazin-10-yl)propan-2-amine
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.006.890
Chemical and physical data
FormulaC16H19N3S
Molar mass285.41 g·mol−1
3D model (JSmol)
  • n2c1N(c3c(Sc1ccc2)cccc3)CC(N(C)C)C
  • InChI=1S/C16H19N3S/c1-12(18(2)3)11-19-13-7-4-5-8-14(13)20-15-9-6-10-17-16(15)19/h4-10,12H,11H2,1-3H3 checkY
  • Key:OQJBSDFFQWMKBQ-UHFFFAOYSA-N checkY
  (verify)

See also

References
  1. Bibas N, Sartor V, Bulai Livideanu C, Bagheri H, Nougué J, Giordano-Labadie F, et al. (2012). "Contact photoallergy to isothipendyl chlorhydrate". Dermatology. 224 (4): 289–291. doi:10.1159/000338024. PMID 22677929. S2CID 27580642.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.