Vilanterol

Vilanterol (INN, USAN) is an ultra-long-acting β2 adrenoreceptor agonist (ultra-LABA), which was approved in May 2013 in combination with fluticasone furoate for sale as Breo Ellipta by GlaxoSmithKline for the treatment of chronic obstructive pulmonary disease (COPD).[1][2]. The combination is also approved for the treatment of asthma in Canada, Europe, Japan[3] and New Zealand.[4]

Vilanterol
Clinical data
License data
Pregnancy
category
  • AU: B3
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only
  • In general: ℞ (Prescription only)
Identifiers
  • 4-{(1R)-2-[(6-{2-[(2,6-Dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.217.751
Chemical and physical data
FormulaC24H33Cl2NO5
Molar mass486.43 g·mol−1
3D model (JSmol)
  • c1cc(c(c(c1)Cl)COCCOCCCCCCNC[C@@H](c2ccc(c(c2)CO)O)O)Cl
  • InChI=1S/C24H33Cl2NO5/c25-21-6-5-7-22(26)20(21)17-32-13-12-31-11-4-2-1-3-10-27-15-24(30)18-8-9-23(29)19(14-18)16-28/h5-9,14,24,27-30H,1-4,10-13,15-17H2/t24-/m0/s1
  • Key:DAFYYTQWSAWIGS-DEOSSOPVSA-N

Vilanterol is available in following combinations:

See also
  • Salmeterol—the long-acting β2 adrenoreceptor agonist (LABA) from which vilanterol was derived.

References
  1. "FDA approves Breo Ellipta to treat chronic obstructive pulmonary disease". Food and Drug Administration. Retrieved 10 May 2013.
  2. McKeage K (September 2014). "Fluticasone furoate/vilanterol: a review of its use in chronic obstructive pulmonary disease". Drugs. 74 (13): 1509–22. doi:10.1007/s40265-014-0269-6. PMID 25074268. S2CID 29379731.
  3. Syed YY (March 2015). "Fluticasone furoate/vilanterol: a review of its use in patients with asthma". Drugs. 75 (4): 407–18. doi:10.1007/s40265-015-0354-5. PMID 25648266. S2CID 24563680.
  4. Zealand (www.bka.co.nz), Site designed and developed by bka interactive ltd, Auckland, New (22 June 2019). "Fluticasone and vilanterol | Health Navigator NZ". Health Navigator New Zealand.{{cite web}}: CS1 maint: multiple names: authors list (link)
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