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Hydrochlorothiazide
From WikEM
Contents
General
- Type: diuretic
- Dosage Forms: 12.5, 25, 50
- Common Trade Names: Microzide, Esidrix
- Must check chem 10 before prescribing in ED
Adult Dosing
- hypertension: 12.5 - 50 MG PO QDAY
Pediatric Dosing
- < 6 months: 2-4mg/kg/day PO BID
- 6 mo - 2 yo: 1-2mg/kg/day PO BID, max 37.5mg/day
- 2 - 12 y/o: 1-2mg/kg/day PO qday-bid, max 100mg/day
Special Populations
- Pregnancy Rating:B
- Lactation: probably safe
- Renal Dosing
- Adult: caution advised
- Pediatric: caution advised
- Hepatic Dosing
- Adult: not defined
- Pediatric: not defined
Contraindications
- Allergy to class/drug
- Anuria
- neonatal jaundice
Adverse Reactions
Serious
*hypokalemia, severe
- arrythmias
- cholestatic jaundice
- pancreatitis
- steven johnson syndrome
- renal failure
- leukopenia
Common
- hypokalemia
- hypochloremia
- hyponatremia
- hypomagnesium
- hypercalcemia
- hyperglycemia
- hyperlipidemia
- dizziness
- diarrhea
- headache
- muscle cramps
Pharmacology
- Half-life: 5.6 - 14.8 hours
- Metabolism: none
- Excretion: urine
- Mechanism of Action: ihibits distal convoluted tubule sodium and chloride resorption
See Also
References
Authors
Babak Missaghi, Ross Donaldson, Neil Young, Daniel Ostermayer
