Lithium citrate

Lithium citrate (Li3C6H5O7) is a lithium salt of citric acid that is used as a mood stabilizer in psychiatric treatment of manic states and bipolar disorder.[1][2][3][4] There is extensive pharmacology of lithium, the active component of this salt.

Lithium citrate
Names
Other names
Trilithium citrate
trilithium 2-hydroxypropane-1,2,3-tricarboxylate
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard 100.011.860
EC Number
  • 213-045-8
RTECS number
  • TZ8616000
UNII
  • InChI=1S/C6H8O7.3Li/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3 checkY
    Key: WJSIUCDMWSDDCE-UHFFFAOYSA-K checkY
  • InChI=1/C6H8O7.3Li/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3
    Key: WJSIUCDMWSDDCE-DFZHHIFOAV
  • [Li+].[Li+].[Li+].O=C([O-])CC(O)(C([O-])=O)CC(=O)[O-]
Properties
Li3C6H5O7
Molar mass 209.923 g mol−1
Appearance Odorless white powder
Melting point decomposes at 105 °C (221 °F; 378 K)
Hazards
GHS labelling:
GHS07: Exclamation mark
Warning
H302, H319
P305+P351+P338
Flash point N/A
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Infobox references

Lithia water contains various lithium salts, including the citrate.

History

An early version of Coca-Cola available in pharmacies' soda fountains called Lithia Coke was a mixture of Coca-Cola syrup and lithia water. The soft drink 7Up was originally named "Bib-Label Lithiated Lemon-Lime Soda" when it was formulated in 1929 because it contained lithium citrate. The beverage was a patent medicine marketed as a cure for hangover. Lithium citrate was removed from 7Up in 1948[5] after it was banned by the Food and Drug Administration.[6]

Lithium citrate is used as a mood stabilizer and is used to treat mania, hypomania, depression and bipolar disorder.[7] It can be administered orally in the form of a syrup.[7]

References
  1. Medication description
  2. "pms-Lithium Citrate - Uses, Side Effects, Interactions - MedBroadcast.com". medbroadcast.com. Retrieved 2017-08-15.
  3. "Medical use". Archived from the original on 2006-06-15. Retrieved 2006-07-29.
  4. "Lithium: medicine to control mood disorders such as mania and bipolar disorder". nhs.uk. 2020-08-17. Retrieved 2022-08-25.
  5. Gielen, Marcel; Edward R. T. Tiekink (2005). Metallotherapeutic drugs and metal-based diagnostic agents: The use of metals in medicine. John Wiley and Sons. p. 3. ISBN 0-470-86403-6.
  6. "Here's the Gross Thing That Happens when You Mix 7-Up with Lithium". 20 February 2016.
  7. PubChem. "Lithium citrate". pubchem.ncbi.nlm.nih.gov. Retrieved 2022-09-08.


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